Contraindicated (1)pentobarbital will lower the extent or impact of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the extent or effect of methadone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.fentanyl iontophoretic transdermal method and pentobarbital both equally ma